Role of phytochemical supplements in prevention of diseases | Homework Helpers


Prepare a powerpoint slides meeting below grading criteria covering topic Isoflavones and Polymethoxyflavones using recent original articles one from cell, frontier and nature. -recent articles related to the mechanisms of action, biological activities and health effects, establishing the dietary intake recommendations, measurements, bioavailability, epidemiology, etc., of phytochemicalsnot more than 20 slides. Work needs to be professional, visually appealing and use rectangular powerpoint slides that will allow you to cover all this concepts. AID your critical analysis at every step to reflect your understand on the topic.

Don't use plagiarized sources. Get Your Custom Essay on
Role of phytochemical supplements in prevention of diseases | Homework Helpers
Get an essay WRITTEN FOR YOU, Plagiarism free, and by an EXPERT!
Order Essay

Part B

1. Discuss, from the mechanistic, evidence-based, and public health policy points of view, the possible role of phytochemical supplements in prevention of chronic diseases (e.g., cancer, obesity, diabetes, Alzheimer’s disease, etc.).

As a starting point, use the editorial “Enough Is Enough: Stop Wasting Money on Vitamin and Mineral Supplements” in the Dec 2013 issue of Ann Intern Med (particularly, the statement: “Evidence is sufficient to advise against routine supplementation, and we should translate null and negative findings into action.”).

Try to separate evidence based on mechanistic knowledge from that based on evidence linking the intervention to a given clinical outcome.

See below the link to the editorial; also read original articles in this issue.

Look at the article published in: Nutrients 2013, 5, 5161-5192; doi:10.3390/nu5125161

2. Review and critique research articles provided in Content – PMFs. Do in vitro anticancer effects of the described PMFs warrant animal studies?

(Articles are attached in separate folder)


Provide with your critical comment and aIDitional insights citing the original articles atleast 5 in support to the each in depth discussion to the below?

a. Fruits and vegetables are said to contain biologically active phytochemicals that are likely to interact in a few ways to prevent disease and promote health. Fruits and vegetables are rich in antioxidants which is known to help prevent the body from oxidative damage induced by pro-oxidants. Studies regarding phytochemicals are becoming increasing popular in treating ailments such as cancer. Since there are so many phytochemicals, three have been chosen to discuss. With regards to lycopene from tomatoes, it was found to inhibit human cancer cell proliferation, and to suppress insulin-like growth factor-I-stimulated growth. This may open new avenues for lycopene studies on the role of the prevention or treatment of endometrial cancer and other tumors. It was also explained that lycopene also possesses inhibitory effects on breast and endometrial cancer cells, prostate cancer cells, and colon cancer cells.

With regards to ginger, gingerol has been studied for its anti-cancerous effects for the tumors in the colon, breast ovaries, and pancreas. A recent review by Oyagbemi et al. summarized the mechanisms in the therapeutic effects of gingerol which explains that gingerol demonstrates antioxidant, anti-inflammation, and antitumor promoting properties, decreases iNOS and TNF-alpha expression via suppression of I?B? phosphorylation and NF-?B nuclear translocation . Treating K562 cells and MOLT4 cells with gingerol, the ROS levels were significantly higher than control groups, inducing apoptosis of leukemia cells by mitochondrial pathway.

Epigallocatechin from tea can be beneficial in treating brain, prostate and cervical and blaIDer cancer. One of the proposed mechanism among many mechanism studied is that EGCG binds and inhibits the anti-apoptotic protein Bcl-xl , a protein involved in both cancer cell and normal cell survival, also EGCG suppresses AOM-induced colonic premalignant lesions, interferes with EGFR signaling, and inhibits hepatocyte growth factor-induced cell proliferation in human colon cancer cells. EGCG has shown inhibition of mitogen-activated protein kinases (MAPK), cyclin-dependent kinases, growth factor-related cell signaling, activation of activator protein 1 and NF-?B, topoisomerase I and matrix metalloproteinases.

b. Yes in vitro anti-cancer effects of the described PMF’s warrant animal studies as results from animal and cells studies are not generalizable to the entire human population as humans are not held in sterile/controlled environments. There are many differences between how isolated cells, animals and humans behave and “operate”, often what works for a particular individual might not work for another; these studies however offer good insight to human behaviors in situations where studies may be unethical.

In the second study posted regarding calcium mediated apoptosis in breast cancer cells the study explained that the results provide evidence for the ant proliferative and pro-aptotic activity of PMF’s in breast cancer cells and supports the hypothesis of MF-induced sustained increase in [Ca2+] is associated with induction of apoptosis in these cells. The findings also strongly imply that induction of apoptosis with PMFs requires activation of the Ca2+-dependent ?-calpain and the Ca2+/calpain-dependent caspase-12 and that hydroxylations of PMFs are critical for enhancing their pro-apoptotic activity. The treatment in this study was rendered only to cells but the looming question is will the treatment work the same on an organ or a human.

In the last study posted, the conclusion was that the findings obtained provided rationale for evaluating the role of PMF’s in the prevention and treatment of obesity. This mouse study provides grounds for investigating PMF’s in obesity treatment in humans but the results should definitely be generalizable to humans.

Calculate your paper price
Pages (550 words)
Approximate price: -

Why Choose Us

Top quality papers

We always make sure that writers follow all your instructions precisely. You can choose your academic level: high school, college/university or professional, and we will assign a writer who has a respective degree.

Professional academic writers

We have hired a team of professional writers experienced in academic and business writing. Most of them are native speakers and PhD holders able to take care of any assignment you need help with.

Free revisions

If you feel that we missed something, send the order for a free revision. You will have 10 days to send the order for revision after you receive the final paper. You can either do it on your own after signing in to your personal account or by contacting our support.

On-time delivery

All papers are always delivered on time. In case we need more time to master your paper, we may contact you regarding the deadline extension. In case you cannot provide us with more time, a 100% refund is guaranteed.

Original & confidential

We use several checkers to make sure that all papers you receive are plagiarism-free. Our editors carefully go through all in-text citations. We also promise full confidentiality in all our services.

24/7 Customer Support

Our support agents are available 24 hours a day 7 days a week and committed to providing you with the best customer experience. Get in touch whenever you need any assistance.

Try it now!

Calculate the price of your order

Total price:

How it works?

Follow these simple steps to get your paper done

Place your order

Fill in the order form and provide all details of your assignment.

Proceed with the payment

Choose the payment system that suits you most.

Receive the final file

Once your paper is ready, we will email it to you.

Our Services

No need to work on your paper at night. Sleep tight, we will cover your back. We offer all kinds of writing services.


Essay Writing Service

You are welcome to choose your academic level and the type of your paper. Our academic experts will gladly help you with essays, case studies, research papers and other assignments.


Admission help & business writing

You can be positive that we will be here 24/7 to help you get accepted to the Master’s program at the TOP-universities or help you get a well-paid position.


Editing your paper

Our academic writers and editors will help you submit a well-structured and organized paper just on time. We will ensure that your final paper is of the highest quality and absolutely free of mistakes.


Revising your paper

Our academic writers and editors will help you with unlimited number of revisions in case you need any customization of your academic papers