Describe the role of properdin in complement fixation | Homework Helpers

Mary is 20 months old and has been hospitalized with a fever, irritability, and moderate dehydration. Blood work suggests a bacterial infection, with elevated neutrophils (>96%; normal: ~70%), although the chest radiograph and urinalysis are normal. Computed tomography (CT) indicated intracranial evidence for generalized edema with some compression of the ventricles. Despite the risk associated with elevated cerebrospinal fluid (CSF) pressure, a lumbar puncture was performed that showed an elevated white cell count. An analysis of the CSF by polymerase chain reaction (PCR) assay revealed the presence of Neisseria meningitidis. Mary has been receiving intravenous antibiotics for 30 hours, and there is some improvement in her condition. Query into the child’s background indicated that Mary had been breast fed until she was 3 months of age and had been relatively healthy until this recent infection. Detailed family history reveals that a distant male cousin and an aunt both died at an early age (<2 years) of meningitis.

Questions for the exam:

Don't use plagiarized sources. Get Your Custom Essay on
Describe the role of properdin in complement fixation | Homework Helpers
Get an essay WRITTEN FOR YOU, Plagiarism free, and by an EXPERT!
Order Essay

1) Mary has a genetically linked immunodeficiency. Unlike many such patients, who had recurrent infections with several gram-negative and/or gram-positive bacteria, Mary has only presented with infection with Neisseria meningitidis. Why is a phagocyte or B cell defect unlikely?

2) The family history revealed that both males and females had presented with this type of infection. What does this indicate? Explain the term autosomal recessive.

3) What molecule or molecules is/are likely missing or defective in Mary?

4) Diagram the alternative pathway of complement fixation.

5) How would deficiencies in the early components of the alternative pathway of complement fixation present clinically?

6) Why is a genetic defect in C3 so devastating?

7) How would a deficiency in CD59 present clinically?

8) List the factors that are responsible for protecting human cells from complement fixation?

9) Describe the role of properdin in complement fixation, and the significance of the fact that the gene that encodes properdin is located on the X chromosome.

10) Why do phagocytes have receptors for modified portions of the C3 and C4 proteins?

Calculate your paper price
Pages (550 words)
Approximate price: -

Why Choose Us

Top quality papers

We always make sure that writers follow all your instructions precisely. You can choose your academic level: high school, college/university or professional, and we will assign a writer who has a respective degree.

Professional academic writers

We have hired a team of professional writers experienced in academic and business writing. Most of them are native speakers and PhD holders able to take care of any assignment you need help with.

Free revisions

If you feel that we missed something, send the order for a free revision. You will have 10 days to send the order for revision after you receive the final paper. You can either do it on your own after signing in to your personal account or by contacting our support.

On-time delivery

All papers are always delivered on time. In case we need more time to master your paper, we may contact you regarding the deadline extension. In case you cannot provide us with more time, a 100% refund is guaranteed.

Original & confidential

We use several checkers to make sure that all papers you receive are plagiarism-free. Our editors carefully go through all in-text citations. We also promise full confidentiality in all our services.

24/7 Customer Support

Our support agents are available 24 hours a day 7 days a week and committed to providing you with the best customer experience. Get in touch whenever you need any assistance.

Try it now!

Calculate the price of your order

Total price:

How it works?

Follow these simple steps to get your paper done

Place your order

Fill in the order form and provide all details of your assignment.

Proceed with the payment

Choose the payment system that suits you most.

Receive the final file

Once your paper is ready, we will email it to you.

Our Services

No need to work on your paper at night. Sleep tight, we will cover your back. We offer all kinds of writing services.


Essay Writing Service

You are welcome to choose your academic level and the type of your paper. Our academic experts will gladly help you with essays, case studies, research papers and other assignments.


Admission help & business writing

You can be positive that we will be here 24/7 to help you get accepted to the Master’s program at the TOP-universities or help you get a well-paid position.


Editing your paper

Our academic writers and editors will help you submit a well-structured and organized paper just on time. We will ensure that your final paper is of the highest quality and absolutely free of mistakes.


Revising your paper

Our academic writers and editors will help you with unlimited number of revisions in case you need any customization of your academic papers