Consider the model of Negative Frequency Dependent Selection introduced in Lecture 3; diploid sexual population, one locus, two alleles (A1, A2), freq(A1) = p, freq(A2) = 1-p = q. The population starts with both alleles present and ignore the effects of random genetic drift. HINT: This problem can be efficiently aIDressed by using a spreadsheet (or other method of simulation, e.g., Populus).
Genotype: A1A1 A1A2 A2A2
Relative fitness (wij) 1-sp2 1-2spq 1-sq2
Let the selection coefficient s = 0.2
b) What are the allele frequencies at equilibrium?
c) What is the population mean fitness at equilibrium? Is it at its maximum?
d) What is the genotypic variance (VG) for fitness at equilibrium?
e) What are the average excesses (?i) of the two alleles at equilibrium?
f) What is the aIDitive genetic variance (VA) at equilibrium?
g) At what allele frequency(s) is VA maximized?
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