Orphan Drugs for Rare Diseases
1. Go to:http://www.accessdata.fda.gov/scripts/opdlisting/oopd/index.cfm
a. In the start date, type 01/01/2010.
b. In the “Search Results”, pull down “Only Approved Products”.
c. In the “Sort results”, pull down to show “Most Recent to Earliest”.
d. In the “Records per Page”, type 100.
e. Press “Run Search”.
f. Pick one drug whose row number is the same as the last 2 digits of your student number. You may need to click on the second page to see your number. Write your student number across your name in your submission.
g. From the table, obtain info on the orphan designation or disease/indication
h. Use Pubmed (http://www.ncbi.nlm.nih.gov/pubmed/?querykey=4%26dbase=pubmed%26querytype=eSearch%26) to find references on the drug and indication (disorder), market size (number of people affected) and discuss the rare disease or condition for which the drug is being or will be investigated, the proposed use of the drug, and the reasons why such therapy is needed. If not much information is available in PubMed about your drug or disease, pick a different drug to work on that is closest to your student ID.
i. Provide a description of the drug, and include the identity of the active moiety if it is a drug composed of small molecules, or of the principal molecular structural features if it is composed of macromolecules; its physical and chemical properties, if they are available.
j. Discuss the scientific rationale or a medically plausible basis for the use of the drug for the rare disease or condition, including all relevant data from in vitro laboratory studies, preclinical efficacy studies conducted in an animal model for the human disease or condition, and clinical experience with the drug in the rare disease or condition, if available.
k. Reference section is required for this homework (Follows citation style for journal that is found in: http://jb.asm.org/site/misc/journal-ita_org.xhtml#02)
Why Choose Us
Top quality papers
We always make sure that writers follow all your instructions precisely. You can choose your academic level: high school, college/university or professional, and we will assign a writer who has a respective degree.
Professional academic writers
We have hired a team of professional writers experienced in academic and business writing. Most of them are native speakers and PhD holders able to take care of any assignment you need help with.
If you feel that we missed something, send the order for a free revision. You will have 10 days to send the order for revision after you receive the final paper. You can either do it on your own after signing in to your personal account or by contacting our support.
All papers are always delivered on time. In case we need more time to master your paper, we may contact you regarding the deadline extension. In case you cannot provide us with more time, a 100% refund is guaranteed.
Original & confidential
We use several checkers to make sure that all papers you receive are plagiarism-free. Our editors carefully go through all in-text citations. We also promise full confidentiality in all our services.
24/7 Customer Support
Our support agents are available 24 hours a day 7 days a week and committed to providing you with the best customer experience. Get in touch whenever you need any assistance.
Try it now!
How it works?
Follow these simple steps to get your paper done
Place your order
Fill in the order form and provide all details of your assignment.
Proceed with the payment
Choose the payment system that suits you most.
Receive the final file
Once your paper is ready, we will email it to you.
No need to work on your paper at night. Sleep tight, we will cover your back. We offer all kinds of writing services.
You are welcome to choose your academic level and the type of your paper. Our academic experts will gladly help you with essays, case studies, research papers and other assignments.
Admission help & business writing
You can be positive that we will be here 24/7 to help you get accepted to the Master’s program at the TOP-universities or help you get a well-paid position.
Editing your paper
Our academic writers and editors will help you submit a well-structured and organized paper just on time. We will ensure that your final paper is of the highest quality and absolutely free of mistakes.
Revising your paper
Our academic writers and editors will help you with unlimited number of revisions in case you need any customization of your academic papers