Calculate the coefficient of coincidence for the cross | Homework Helpers

Suppose you infect E. coli cells with two strains of T4 virus. One strain is minute (m), rapid lysis (r) and turbid (t); the other is wild-type for all three markers. The lytic products of this dual infection are plated on a lawn of E. coli and the morphology of the plaques are classified. The resulting 10, 342 plaques were distributed among eight phenotypes, as follows:

m r t 3467
+ + + 3729
m r + 853
m + t 162
m + + 520
+ r t 474
+ r + 172
+ + t 965

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You decide to repeat the exact same experiment as outlined above and this time you count and classify 25, 000 plaques? How many plaques would you expect to be wild-type for all three markers? (Hint: You will need to calculate the coefficient of coincidence for the cross above and apply that to your answer.)

 

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