Colorado Christian University Corona Virus Disease Video Worksheet I have a video that you need to watch and answers the questions below. This needs to be

Colorado Christian University Corona Virus Disease Video Worksheet I have a video that you need to watch and answers the questions below. This needs to be completed based on the video that is attached with the worksheet. Video link will be provided in the word document. Video Link : Watch this video: https://youtu.be/ae__pSn1vGA
COVID 19 Assignment
Name____________________________
Based on the info in the Coronavirus lecture, answer these questions:
1. For COVID 19, list theetiologic agent:
mode(s) of transmission:
possible reservoir(s):
incubation period:
List three signs of the disease:
List two symptoms of the disease:
2. Scientists identified the causative agent of SARS using Koch’s postulates. As mentioned
in the lecture, primates were used as experimental hosts. Using this info, outline the
basic steps that led to the discovery of the causative agent of SARS-
3. Suppose you performed a differential blood count on a blood sample obtained from a
COVID-19 patient. For every 100 leukocytes observed, 80 were neutrophils and 9 were
lymphocytes. Using info from the coronavirus lecture and immunology lectures and/or
labs- Select the true statement:
a) These neutrophil and lymphocyte counts are within the normal ranges; no cause for
concern.
b) These lymphocyte counts are lower than normal (lymphopenia); patient needs to be
closely monitored.
c) These lymphocyte counts are higher than normal- this means the patient is entering the
decline phase and should feel better soon.
d) The neutrophil: lymphocyte ratio is less than 3, so we expect the severity of the disease
to be low for this patient.
4. Explain how Coronaviruses may prevent innate anti-viral immune responses from taking
place (in your answer mention, PAMPs, PRRs, and the type of inhibitor involved).
5. How does the Coronavirus attach to and enter host cells?
6. What is the function of the RNA-dependent RNA polymerase?
7. What is the function of the protease?
8. Select the true statement regarding the life cycle:
a) The viral genome can serve directly as mRNA.
b) The viral genome is reverse-transcribed into DNA.
c) The virus uses a host RNA polymerase to transcribe its genes.
d) The virus receives its envelope from the plasma membrane of the host cell.
9. In the lecture, I talked about mutations in the gene coding for the civet glycoprotein
spike, and how this influenced human host receptor binding. Use the codon chart
(below) to answer these questionsa. Suppose the 479th codon in the mRNA reads “AAA”- this codes for which amino acid?
b. If you wanted to perform a single basepair substitution so you have an Asparagine at
this position, how could you do it?
c. What kind of mutation is this (nonsense, silent, missense?)
d. The 472nd codon is “CUU” in the civet spike mRNA. In the human spike mRNA, it is “CUC”
at this position. What kind of mutation is this (nonsense, silent, missense)?
10. When I showed the crystal structure of the SARS-COV2 protease, the small molecule
bound to it was a:
a)
b)
c)
d)
Non-competitive inhibitor
Competitive inhibitor
Allosteric inhibitor
Allosteric activator
11. What is Convalescent plasma? Is this an example of active or passive immunity?
Naturally or artificially Acquired immunity? Will this result in immunological memory
(long-lasting immunity?)
12. One possible therapeutic not discussed in the lecture is a drug that is a soluble form of
human ACE2. Why might this work as an antiviral therapy?
13. Suppose you were viewing the results of the rapid antibody test described in the
lecture.
a. If the patient is IgM+/IgG – how do you interpret these results?
b. If the patient is IgM- /IgG+ – how do you interpret these results?
c. If the patient is IgM- /IgG-, how do you interpret these results? Is it possible for a
patient to be infected with the Coronavirus and have these results? Explain why.

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